Publications: 1986-1990

Martin, J.L., Johnson, L.N. and Withers, S.G. (1990) Biochemistry 29, 10745-10757 “Comparison of the binding of glucose and glucose-1-phosphate derivatives to T-state glycogen phosphorylase b”. Pubmed


Berven, L.A., Dolphin, D. and Withers, S.G. (1990) Can. J. Chem. 68, 1859-1866 “The base-catalysed anomerisation of dinitrophenyl glycosides: evidence for a novel reaction mechanism”.


Withers, S.G., Warren, R.A.J., Street, I.P., Rupitz, K., Kempton, J.B. and Aebersold, R. (1990) J. Amer. Chem. Soc. 112, 5887-5889 “Unequivocal demonstration of the involvement of a glutamate residue as a nucleophile in the mechanism of a “retaining” glycosidase”.


Withers, S.G. and Rupitz, K. (1990) Biochemistry 29, 6405-6409 “Measurement of active site homology between potato and rabbit muscle a -glucan phosphorylases through use of a linear free energy relationship”. Pubmed


Bird, P., Dolphin, D.H. and Withers, S.G. (1990) Can. J. Chem. 68, 317-322 “The synthesis of protected 5-azido-5-deoxy-D-glucononitriles as precursors of glycosidase inhibitors”.


Withers, S.G. (1990) Carbohydr. Res. 197, 61-73 “The enzymic synthesis and NMR characterisation of specifically deoxygenated and fluorinated glycogens”.


Caron, G and Withers, S.G. (1989) Biochem. Biophys. Res. Commun. 163, 495-499 “Conduritol aziridine: A new mechanism-based glucosidase inactivator”. Pubmed


Withers, S.G., Percival, M.D. and Street, I.P. (1989) Carb. Res. 187,43-66 “The synthesis and hydrolysis of a series of deoxy- and deoxyfluoro- a -D-glucopyranosyl phosphates”.


Withers, S.G. and Street, I.P. (1989) in ACS Symposium Series, Biogenesis and Biodegradation of Plant Cell Wall Polymers, Vol 399, 597-607. ” b -Glucosidases: their mechanism and their inhibition”.


Street, I.P., Rupitz, K. and Withers, S.G. (1989) Biochemistry 28, 1581-1587 “Fluorinated and deoxygenated substrates as probes of transition state structure in glycogen phosphorylase”. Pubmed


Withers, S.G. and Street, I.P. (1988) J. Amer. Chem. Soc. 110, 8551-8553 “Identification of a covalent a -D-glucopyranosyl-enzyme intermediate formed on a b -glucosidase”.


Percival, M.D. and Withers, S.G. (1988) Can. J. Chem. 66, 1970-1972 “Applications of enzymes in the synthesis and hydrolytic study of 2-deoxy- a -D-glucopyranosyl phosphate”.


Berven, L.A., Dolphin, D.H. and Withers, S.G. (1988) J. Amer. Chem. Soc. 110, 4864-4866 “A novel mechanism of glycoside anomerization”.


Withers, S.G., Rupitz, K. and Street, I.P. (1988) J. Biol. Chem. 263, 7929-7932 “2-Deoxy-2-fluoro-D-glucosyl fluorides: A new class of specific mechanism-based glycosidase inhibitors”. Pubmed


Withers, S.G., Street, I.P. and Percival, M.D. (1988) in ACS Symposium Series, FLUORO CARBOHYDRATES Vol 374, 59-77 “Fluorinated carbohydrates as probes of enzyme specificity and mechanism”.


Withers, S.G., Street, I.P., Bird, P., and Dolphin, D.H. (1987) J. Amer. Chem. Soc. 109, 7530-7531 “2-Deoxy-2-fluoro-glucosides: A novel class of mechanism-based glucosidase inhibitors”.


Holme, K.R., Hall, L.D., Armstrong, C.R. and Withers, S.G. (1987) Carb. Res. 173, 285-291 “Synthesis and evaluation of chitosan-based affinity chromatography materials”. Pubmed


Goldsmith, E.J., Fletterick, R.J. and Withers, S.G. (1987) J. Biol. Chem. 262, 1449-1455 “The three-dimensional structure of acarbose bound to glycogen phosphorylase”. Pubmed


Berven, L.A. and Withers, S.G. (1986) Carb. Res. 156, 282-285 “A convenient and high-yielding synthesis of 1,2,3,4,6-penta-O-acetyl-1- b -D-[ 2 H]-glucopyranose”.


Street, I.P., Armstrong, C.R. and Withers, S.G. (1986) Biochemistry 25, 6021-6027 “Hydrogen bonding and specificity. Fluorodeoxy sugars as probes of hydrogen bonding in the glycogen phosphorylase-glucose complex”. Pubmed


Day, A.G. and Withers, S.G. (1986) Can. J. Biochem. 64, 914 “The purification and characterisation of a b -glucosidase from Alcaligenes faecalis”. Pubmed


Withers, S.G., MacLennan, D.J. and Street, I.P. (1986) Carb. Res. 154, 127-144 “The synthesis and hydrolysis of a series of deoxyfluoro-D-glucopyranosyl phosphates”.


Withers, S.G., Dombroski, D, Berven, L., Kilburn, D.G., Miller, R.C.Jr., Warren, R.A.J. and Gilkes, N.R. (1986) Biochem. Biophys Res. Commun. 139, 487-494 “Direct 1 H-NMR determination of the stereochemical course of hydrolyses catalysed by glucanase components of the cellulase complex”. Pubmed


Street, I.P. and Withers, S.G. (1986) Can. J. Chem. 64, 1400-1404 “Fluorination of protected mannose derivatives using diethylaminosulfur trifluoride”.


Withers, S.G. and Street, I.P. (1986) Can. J. Chem. 64, 232-236 “The preferred conformation of 2-deoxy-2-fluoro- b -mannopyranosyl fluoride. An X-ray crystallographic and 2-dimensional N.M.R. study”.


Madsen, N.B. and Withers, S.G. (1986) in “Pyridoxal Phosphate and Derivatives” Eds. D. Dolphin, R. Poulsen and O. Avramovic, J. Wiley and Sons, New York “Glycogen phosphorylase”.